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According to the Medicare website, a participant must be: A Medicare recipient with a Part D prescription plan who is 18 years or older, and: Have a body mass index of 35 or greater, or: A body mass index of 30 or greater and heart failure with preserved ejection fraction, uncontrolled hypertension or chronic kidney disease, or: A BMI of 27 or greater and pre-diabetes, a previous myocardial infarction, previous stroke or symptomatic peripheral artery disease

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Simultaneously, it activates the cAMPPKACREB axis to upregulate IL-10