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Abbreviations A: Amyloid- Ach: Acetylcholine AChE: Acetylcholinesterase ACR-16: Acetylcholine Receptor subunit alpha-type AD: Alzheimers disease AMPK: AMP-activated protein kinase APP/PS1: Amyloid precursor protein / Presenilin 1 BBB: Blood-brain barrier Bcl-2: B-cell lymphoma 2 BDNF: Brain-derived neurotrophic factor BEC-1: Beclin homolog CAT: Catalase COX: Cyclooxygenase CNS: Central nervous system CREB: cAMP response element-binding protein CX3CL1: C-X3-C motif chemokine ligand 1 CX3CR1: C-X3-C motif chemokine receptor 1 GFAP: Glial fibrillary acidic protein GM-CSF: Granulocyte macrophage colony stimulating factor GPx: Glutathione peroxidase GSH: Glutathione GSK-3: Glycogen synthase kinase 3 Beta GLUT3/4: Glucose transporter 3 / 4 HST: Hesperetin HSD: Hesperidin Iba-1: Ionised calcium-binding adaptor molecule 1 IFN-: Interferon IL-17: Interleukin 17 IL-1: Interleukin-1 beta iNOS: Inducible nitric oxide synthase IR: Insulin receptor JAK/STAT3: Janus kinase / Signal transducer and activator of transcription 3 LPS-stimulated: Lipopolysaccharide MAPK: Mitogen-activated protein kinase MDA: Malondialdehyde MTX: Methotrexate mPTP 1: Methyl-4-phenyl-1,2,3,6-tetrahydropyridine mTOR: Mechanistic target of rapamycin NADH: Nicotinamide Adenine Dinucleotide Hydrogen NADPH: Nicotinamide adenine dinucleotide phosphate NF-b: Nuclear factor kappa-light-chain-enhancer of activated B cells NK: Natural killer Nrf2: Nuclear factor erythroid 2-related factor 2 N2a: Neuro-2a cell OS: Oxidative stress PD: Parkinsons disease PD-L1: Programmed death-ligand 1 PGE2: Prostaglandin E2 PPAR: Peroxisome proliferator-activated receptor p70S6K : 70-kDa ribosomal protein S6 kinase PI3K-Akt: Phosphatidylinositol 3-kinase ROS: Reactive oxygen species RNS: Reactive nitrogen species SOD: Superoxide dismutase STAT3: Signal transducer and activator of transcription TBARS: Thiobarbituric acid reactive substances T-cell: Thymus cell TGF-1: Transforming growth factor beta 1 TNF-: Tumor necrosis factor-alpha TLR4: Toll-like receptor 4 TrkB: Tropomyosin receptor kinase B VDAC1: Voltage-dependent anion channel 1 VEGF: Vascular endothelial growth factor References Adamu A, Li S, Gao F, Xue G (2024) The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets