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This approach is more common in research settings than clinical practice, but some providers believe it optimizes the balance between efficacy and side effects by tailoring the dose to individual body size

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References Reitzer L: Nitrogen assimilation and global regulation in Escherichia coli

The titration schedule from clinical trials follows a gradual escalation

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Absorbance was read at 450 nm using a microplate reader, and hormone concentrations were derived from standard calibration curves