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These are unstable molecules that can cause oxidative stress a state of biological imbalance that can lead to cellular damage over time

Study Design Considerations Research protocols must specify exact dosing schedules and concentrations

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Specific Dosage Guidelines Severe Deficiency : For patients with severe vitamin B12 deficiency, an initial dose of 1 mg (1000 g) of intramuscular hydroxocobalamin is commonly administered

doi:10.1016/j.bbagen.2012.09.018