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The study (2) has suggested that the peptide binds with the histones - HI/6 and HI/3 located at different sites in tissue, which then interact with the DNA

10.1038/s41582-018-0047-2 21 BannwarthS.Ait-El-MkademS.ChaussenotA.GeninE

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Now it seems oral small-molecule GLP-1s also dial back eating for pleasure by engaging a brain reward circuit. Given the effect of these drugs on eating for pleasure, future studies could explore whether small-molecule GLP-1s can also suppress cravings for other addictive substances