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follow your trial team's hypoglycaemia management plan Severe or persistent changes in mood, or any thoughts of self-harm or suicide whilst a causal link between GLP-1-based medicines and mood changes has not been established (regulatory reviews, including by the EMA, are ongoing), any significant psychological symptoms should be reported promptly [13] [14] Any allergic reaction, including rash or skin changes It is also important to report any new or worsening symptoms to your trial team, even if they seem minor