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3 Unfortunately, despite an improvement in the clinical response and an increase in the average survival, 6080% of patients still experienced ineffectiveness of the therapy used and disease relapse within 5 years, which is due to the resistance of tumors to the cytostatic treatment

The normalization of oxidative stress markers (MDA, SOD, and GSH) and inflammatory markers (IL-17, TNF-, IL-6, and CRP) by PTX-CSNPs suggested a synergistic mechanism: chitosans intrinsic antioxidant properties combined with PTXs ability to inhibit TNF- and oxidative pathways

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