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During the subacute phase of the pathology, lactate can be utilized as an alternative energy source by some surviving neurons and astrocytes, while concurrently promoting angiogenesis and tissue repair through receptor-mediated signaling (129)
Intraperitoneal administration of Re (20 mg/kg) for 12 days decreased fasting blood glucose levels in ob/ob mice [32]
The autophagy machinery controls cell death switching between apoptosis and necroptosis
Decades of research have shown that immune metabolism serves as a determinant of macrophage function, regulating macrophage differentiation, mobilization, and antitumor responses [353]
doi:10.1210/en.2002-220670
Long-term safety remains under study
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