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Macrophage polarization and diabetic wound healing
Shen J, Li J, Wang B et al
While decreased FGF21 receptor expression has been proposed to underlie this FGF21-resistant state, (73), the dramatic upregulation of fibroblast activation protein (FAP), an endopeptidase that cleaves and inactivates endogenous FGF21 (74), has been reported in liver and serum of patients with metabolic liver disease (7577)
Studied in models involving nicotinamide N-methyltransferase signaling, methylation-linked metabolism, and metabolic pathway regulation
