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Hormonal Health: Check thyroid, sex hormones and metabolic labs hormonal imbalances can blunt the effectiveness of GLP-1 therapies
The SUSTAIN 7 trial (Pratley et al., Lancet Diabetes & Endocrinology 2018) reported severe hypoglycemia in 2.5% of patients on semaglutide plus basal insulin vs 0.4% on semaglutide alone
Our semaglutide to tirzepatide conversion chart and the broader semaglutide vs tirzepatide comparison page cover the evidence-based equivalencies that providers use when transitioning patients between these medications
If persistent insomnia, adjust dose timing or consider behavioral sleep strategies first
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