2 (0.2%) placebo-treated patients during clinical trials of semaglutide injection used for weight management
The injected hydroxocobalamin is transported via the bloodstream to tissues throughout the body, where it acts as a cofactor for two critical enzymatic reactions: the conversion of homocysteine to methionine and the conversion of methylmalonyl-CoA to succinyl-CoA
These are administered by healthcare professionals according to NHS protocols
Some patients, particularly those with neurological involvement, may benefit from more frequent dosing (every 2 months rather than 3 months), but this should be medically supervised rather than self-adjusted
Those differences may affect how researchers expect the medicines to work, but they do not make the products interchangeable
A more serious, chronic deficiency, however, is something that builds up over time with regular, heavy drinking