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Therefore, more research should explore the role TIMP-2 and MMP-2 may have in PTSD, and how they not only relate to central oxidative stress processes, but common somatic comorbidities in PTSD as well

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Disruption at any pointsubstrate limitation, enzymatic insufficiency, impaired NADPH availability, or excessive oxidative burdendrives this ratio downward, shifting cells toward an oxidized redox state

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