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Optimal dosing varies based on body weight, body composition goals, and individual metabolic factors

Furthermore, SGLT2i activate autophagy, a pathway that, when deregulated, contributes to kidney damage, by inhibiting mTOR signaling and activating adenosine monophosphate-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) [155, 165, 171]

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[16] Patients with chronic kidney disease (CKD) require particular caution, as impaired renal potassium excretion increases the risk of hyperkalaemia

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Hackett PT, Jia X, Li L, Ward DM