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and research support from Biogen, MSD, Takeda, and Pfizer
However, the medications it prescribes are compounded formulations that have not undergone FDA clinical trials
10.1016/j.cld.2017.08.014 17
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Serious adverse effects , though rare, can include pancreatitis, gallbladder problems, and kidney complications
In response to oxidants, cysteine modification on Keap1 releases NE2FL2, which is then stabilized and transported to the nucleus where it activates transcription of antioxidant genes, including proteasomal PA28
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