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PMCID: PMC10224484

Bioavailability of free testosterone in the blood was shown to be minimal at only 23% in males, as the remainder of gonadal testosterone is sequestered strongly by high affinity steroid hormone binding globulin (SHBG) (~ 44% in males and ~ 66% in females), with a smaller amount (~ 50% in males and ~ 30% in females) weakly bound to low affinity albumin or corticosteroid binding globulin [63]

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doi: 10.1016/j.hjc.2018.11.008 43 Rico-FontalvoJReinaMSolerMJUnigarro-PalaciosMCastaeda-GonzlezJPQuinteroJJet al

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