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Contraindications Tirzepatide, whether compounded or brand-name, should not be used by individuals with a personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, severe gastroparesis or gastrointestinal disease, or during pregnancy

The preparation is standardised prior to use, allowing researchers to work with a consistent peptide composition and eliminating variability associated with solution preparation

Changing the base semaglutide dose may make it less effective for weight loss