Newer dual agonists, such as tirzepatide (which targets both GLP-1 and GIP receptors), may have different tolerability profiles, though they can also cause similar gastrointestinal effects
This is an important consideration for future studies due to the larger effect size in risk of PDAC observed in patients with new onset compared with longstanding diabetes (typically defined as 3 years duration) 46
It plays a vital role in the mitochondria, which are the powerhouses of your cells
For example, in a laboratory-based self-administration study, semaglutide was associated with significant reductions in both alcohol consumption and craving compared to placebo
Similarly, if you have a history of gallbladder issues or active cholecystitis, rapid weight loss from either agent can increase gallstone risk
If you are experiencing visible varicosities, leg heaviness, swelling, cramping, or restless legs, a consultation with a CVR vein specialist is the appropriate next step