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The observed changes in total and LDL cholesterol during semaglutide treatment in our cohort were in line with a systematic review and meta-analysis addressing the efficacy and safety of GLP-1 RAs on body weight and cardiometabolic parameters in individuals with obesity and without diabetes and with a systematic review and meta-analysis of semaglutide 2.4 mg including the 2-year STEP 5 trial (40, 41)

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Vitamin B12 is a water-soluble vitamin that acts as a cofactor for methionine synthase and methylmalonyl-CoA mutase, supporting nerve function, red blood cell production, and DNA synthesis

Here is an incomplete list of medications commonly used by people with type 2 diabetes which list fatigue or tiredness as adverse reactions: Metformin: The most commonly used medication for type 2 diabetes can increase the risk of vitamin B12 deficiency, which can cause people to feel tired or weak

doi: 10.1089/jwh.2010.2128

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