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Here, we review the role of GLP-1 and the actions of associated therapies on glucose metabolism, the gutrenal axis, classical renal risk factors, and renal end points in randomized controlled trials of GLP-1 receptor agonists and DPP-4 inhibitors in patients with T2DM

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As expected, KG-501 treatment reduced the GLP-1 induced transcription of FNDC5 to the basal level (Supplementary Figure S3D)