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3.3.2 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal (4-HNE) is a lipid peroxide produced by polyunsaturated fatty acids (PUFAs) in response to oxidative stress (Figure 3)

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Thus, ferroptosis can be defined as a non-apoptotic mode of regulated cell death, driven by iron accumulation and membrane lipid peroxidation when GPX4 activity is inhibited (Fig