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Its advantages in overcoming drug resistance are: 1) Oral formulations are delivered through albumin binding or nanocarriers to avoid insufficient uptake caused by low hENT1 expression (D et al., 2025), and in pancreatic cancer models, the efficacy is 30% higher than that of intravenous formulations
Mental health concerns, including anxiety and depression, especially with semaglutide, were also notable but occurred less often than GI symptoms, with Wegovy showing the highest depression mention rate
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Angela Fitch, chief medical officer of Knownwell, a primary care and obesity medicine provider, and past president of the Obesity Medicine Association
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