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Superoxide is known to denature enzymes, oxidize lipids, and fragment DNA

The comparability of patient characteristics between two study groups was achieved by the three-step matching on (1) the index date, (2) prior exposure to GLAs in the year before the index date, and (3) patient demographic and clinical characteristics (e.g., diabetes severity, comorbidities, co-medications for cardiovascular diseases [CVDs]) using the propensity score matching approach [6]

Berberine further improves hepatic detoxification efficiency, significantly reduces lipid accumulation, and stabilizes mitochondrial function

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Then maintenance treatment can begin

In addition, they play a role in dominant follicle selection, as regressing follicles undergo a process of apoptosis which is promoted by ROS