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doi: 10.1016/j.nutres.2012.03.012 113 DhamaKLatheefSKDadarMSamadHAMunjalAKhandiaRet al
Enhancing GSH, mainly through NAC, GSH precursors rich in cysteine (whey protein, whey protein isolate rich in cysteine) or pro-GSH compound administration, becomes a potential treatment option for inflammatory diseases by reducing oxidative stress and cytokine expression especially in diabetic patients that also are at risk of more severe COVID-19 disease (299)
In endometriotic cells, ferroptosis resistance mechanisms are up-regulated, including increased expression of GPx4 and GSH, and fibulin 1 (FBLN1) which inhibits ferroptosis, thereby promoting cell survival and lesion progression
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Furthermore, investigations have shown that phthalates can change the expression of genes important for reproductive purpose, therefore compromising the structural integrity and functionality of sperm
Glutathione is a tripeptide (containing 3 amino acids: cysteine, glutamic acid, and glycine) naturally made in human cells that functions as a powerful antioxidant
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