In the presence of high concentrations of polyamines the ribosome frameshifting occurs resulting in the synthesis of functional antizyme 1 which comprises amino acids from both ORF1 and ORF2
Normal immune signaling stays intact
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Sci Transl Med (2019) 11:eaav0936
According to multiple meta-analyses, MTHFR C677T and A1298C increase the relative risk for high homocysteine, cardiovascular disease, stroke, neural tube defects, certain pregnancy issues, depression, migraines, and some neuropsychiatric conditions, especially with low folate/B vitamins.[ref] These same variants can lower the risk for certain conditions as well, illustrating tradeoffs of both positive and negative effects
Alopecia Areata (AA) Alopecia areata is an autoimmune disease in which the immune system attacks hair follicles, causing patchy hair loss even though the follicles can still produce hair