10.7326/0003-4819-121-12-199412150-00009 50 FukudaS.NojimaJ.MotokiY.YamagutiK.NakatomiY.OkawaN.et al
C-type natriuretic peptide regulates sperm capacitation through cGMP/PKG, promotes Leydig cell proliferation and testosterone synthesis, and exerts anti-inflammatory and protective effects in animal models of male reproductive disorders
This was a randomized, double-blind, placebo-controlled trial
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On the basis of results of the most recent CVOTs (DAPA-HF, DAPA-CKD, EMPEROR-R), the FDA has approved dapagliflozin (2020) and empagliflozin (2021) to reduce risk for CV death and HF hospitalization in adults with HF and reduced ejection fraction regardless of whether they have diabetes [24, 25]