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Discovery of MK-8189, a highly potent and selective PDE10A inhibitor for the treatment of schizophrenia
HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimers disease
Purity reported between 98.7% and 99.2% consistent with what we measured in-house by HPLC
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These were further chelated by Mn ions for serving as a magnetic resonance imaging (MRI) contrast agent and PEGylated (HMONs-MnPpIX-PEG) [66]
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