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Additionally, metformin enhances insulin sensitivity in skeletal muscle and adipose tissue, improving glucose uptake
GLP-1 receptor activation suppresses appetite signaling and slows gastric emptying, effects already well-established through earlier-generation peptides like semaglutide
JAMA Otolaryngology-Head & Neck Surgery
Their most recent estimate, published in August 2025 as a preprint, finds that 2.1m to 3.1m lives per year could be saved in patients with diabetes and/or obesity (the larger number includes all patients with obesity whether or not they have cardiovascular disease)
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