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Intravenous delivery is minimally invasive, but many cells are retained in the lungs, spleen, or liver

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Using immunostaining and ELISA techniques, we found that both MTX and CCl 4 (4 weeks) intraperitoneal (i.p.) administration produced a marginal increase in the concentrations of TNF-, IL-1, IL-6, and NF-B p65 inflammatory cytokines

The choice between subcutaneous and intramuscular administration may depend on the formulation, the patients body composition, and the clinics experience

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