In 2015, a Cognitive Vitality Report released by the Alzheimers Drug Discovery Foundation stated that two multi-year treatment trials had found that epithalamin, from which epitalon is isolated, had imparted no severe adverse events in older adults, and that preclinical trials supported a favorable safety profile.35 Ten years later, a systematic review published in 2025 stated that information regarding critical issues about this peptides safety is missing.1 In terms of human trials, the best case we have in support of epitalons safety is a 2002 trial involving 162 patients in which no one in the epitalon group reported serious side effects.36 At the same time, the U.S
C., & Kuo, K
In PD, misfolded and aggregated -synuclein produces insoluble inclusions called Lewy bodies and Lewy neurites [6]
Some got around this by supplementing with N-acetyl cysteine, which is a precursor to glutathione
Taken together, these data demonstrate that mitochondrial function is intrinsically linked to 5FU sensitivity, and that its inhibition may provide an opportunity to increase 5FU efficacy
Low-dose prednisolone (0.3 mg/kg/day) has also been used for vitiligo