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( b ) The local effects of position-4 substitution on the fraction of helical secondary structure during simulations

The secondary end points were AMG 133 PK parameters, including t max and t 1/2

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MR-PRESSO detected outliers in the overall associations with diabetes, LDL-cholesterol, HDL-cholesterol, apolipoprotein B and diastolic blood pressure, and sex-specific association with LDL-cholesterol, HDL-cholesterol, and apolipoprotein B (shown in Additional file 1: Table S5), where we used corrected estimates from MR-PRESSO