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Here's what you need to know, along with what one expert has to say

Eli Lilly submitted the orforglipron NDA to the FDA in Q1 2026 following ATTAIN Phase 3 trial data showing 14.7% body weight reduction at 45mg positioning the worlds first oral small molecule GLP-1 receptor agonist for obesity for anticipated FDA approval in late 2026 or 2027

Any provider selling "mega doses" or "custom high-dose protocols" is operating outside evidence-based practice

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