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Second, these drugs lack specificity, exhibit short intraocular half-lives, and may induce side effects when acting on other ocular structures ( 6.2 Pathway inhibitors targeting the mechanism of PVR Unlike the aforementioned clinical trial drugs, the following candidate drugs represent highly promising preclinical strategies capable of precisely targeting key pathways in the pathogenesis of PVR, such as the TGF-, MAPK, and PI3K/AKT pathways
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This usually does not matter clinically, but it is another reason to store properly and not stretch vials beyond their labeled expiration
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