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Stay at current dose if: GI symptoms are still present but manageable
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This pattern aligns with B12 pharmacokinetics: serum levels peak 8-12 hours post-injection, tissue saturation occurs over 48-72 hours (Andrs et al., Journal of Blood Medicine , 2018)
HCV induces ER stress and alters ER calcium homeostasis, leading to oxidative stress 98
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Downregulation of the Arg/N-degron pathway sensitizes cancer cells to chemotherapy in vivo
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