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PMID: 37749552 J Neuroinflammation -adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery

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There is the classically activated M1 macrophage state associated with pro-inflammatory effects, anti-tumor signals, stimulation of cytotoxic T-cells, secretion of cytokines like interleukin (IL)-12, tumor necrosis factor alpha (TNF-), reactive oxygen species (ROS) and essentially activity to kill tumor cells and pathogens (60)