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The FDA prescribing information for Wegovy (semaglutide) reports musculoskeletal painincluding back pain and extremity painas possible side effects, as does the prescribing information for Zepbound (tirzepatide)

While microneedle patches and advanced delivery technologies are under investigation in preclinical and early clinical studies, no products have completed the FDA approval process

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Before starting tirzepatide, a comprehensive assessment should include: Baseline renal function tests : Measure serum creatinine and calculate eGFR to establish a reference point