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This updated formulation is established with comparable mean exposure and peak concentration

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Because it activates both, it's often called a "dual agonist." The FDA has described tirzepatide (brand name Zepbound) as the first medication of its kind to activate both of these receptors for weight management, and it was approved for that use in November 2023

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Seek urgent medical attention if you develop persistent severe abdominal pain (especially if radiating to the back), with or without vomiting, as these could be symptoms of pancreatitisa rare but serious potential complication of GLP-1 based therapies

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