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Furthermore, the SELECT trial showed a 20% reduction in major adverse cardiovascular event risk in patients with obesity and without diabetes who lost weight with semaglutide treatment 10

Altered GLP-1 function has been observed in type 2 diabetes, obesity, and metabolic syndrome, though there is no routine clinical test to measure GLP-1 activity in standard NHS practice

The researchers built study cohorts with information taken from the U.S

This framing also explains why GLP-1s may be most effective early in the disease continuum, or as part of preventive strategies aimed at preserving cerebral blood flow, metabolic health, and mitochondrial resilience before irreversible neurodegeneration takes hold [14,15]

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