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Clinical studies on the dual GIP/GLP-1 receptor agonist, tirzepatide Tirzepatide has demonstrated significant weight loss effects in phase III clinical trials

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Regulatory agencies have increasingly mandated the inclusion of diverse populations in funded research, reinforcing the urgency of addressing intersectionality and social determinants of health in clinical trial design [631, 632]

A 2023 meta-analysis in Nature identified GLP-1R signaling in immune cells, prompting cautious clinical interest in autoimmune patient populations