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In contrast, we found a larger amount of evidence over 26 studies assessing depressive symptoms in populations with comorbid physical health conditions undergoing GLP-1RA treatment (Table 5)

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Altogether, when administering GLP-1RA plus SGLT2i combination therapy, it is important to adopt an individualized approach to therapy taking into account individual preferences, costs and coverage, toxicity profile, consideration of kidney function and glucose-lowering efficacy, desire for weight loss, and comorbidities

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