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Studies have shown that the intracellular LIP level is regulated by ferritin (Reichert et al., 2020), and in ferroptosis, ferritinophagy increases LIP (Lane et al., 2018)

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The action of hydroxyl free radical on PUFA is the generation of lipid peroxides that represent a major source of electrophilic aldehydes

Persistent or severe reactions may indicate sensitivity to benzyl alcohol in bacteriostatic water

As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19