Cleveland Clinic 2025 Assessed and Endorsed by the MedReport Medical Review Board
Underwood CF, Parr-Brownlie LC
Fatigue is frequently attributed to poor sleep or a stressful week
The molecule, bioengineered from sucralfatea safe, oral, non-systemic small molecule with a 40-year safety recordoffers a novel approach to gastrointestinal modulation
However, in a sensitivity analysis of the REWIND study with dulaglutide, the relative risk reduction for a 40% or 50% decrease in eGFR was 30% and 44%, both significant, in the dulaglutide group compared to placebo, respectively.92 This lower risk of developing macroalbuminuria was also confirmed in an exploratory analysis of the ELIXA (lixisenatide) study.93 In the EXSCEL study (exenatide LAR), renal episodes were analyzed as additional microvascular episodes, and no differences were observed in the risk of episodes related to decreased eGFR, but differences were observed in the composite episode, which included decreased eGFR and macroalbuminuria, although only after adjustment94 (Table 2)
Semaglutide should not be used by people who have a history of pancreatitis