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Specifically, regarding mitochondrial dysfunction, only the older adult cohort treated with GlyNAC significantly lowered 65% mitochondrial glucose oxidation (MGO), and upregulated 78% mitochondrial fatty-acid oxidation (MFO) towards levels not different from the young adult group
Nucleotide-binding oligomerization domain (Nod)-like receptor (NLR) signaling via pattern recognition receptors also depends on PPP flux, which can affect intracellular sensing by macrophages of pathogens, such as Aspergillus (17)
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10.2147/JIR.S306849 113 ZafarS.YaddanapudiS
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