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FGFR2c and KLB (the gene encoding -Klotho) are induced upon exposure to FGF21 or an FGF21 analog, consistent with enhanced sensitivity to FGF21s metabolic effects (101)
However, we did not have information of the disease severity at the sampling time (Supplementary Table 6, Fig
Mitochondrial turnover is controlled by signaling molecules such as Bcl-2, which inhibit apoptosis and BAD/BAX signaling, which induces apoptosis and mitophagy
Animals deficient for this receptor are protected from obesity-induced hepatic steatosis, hyperinsulinemia, hypertriglyceridemia and hyperglycaemia
