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By integrating these data, the paper supports the valorization of antioxidant interventions as an emerging direction in the management of pediatric nephrotic syndrome and substantiates the need for controlled clinical trials, with rigorous design, in this field
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Treatment with rapamycin, a known inducer of autophagy, led to an increase in LC3B puncta and a decrease in P62, whereas treatment with wortmannin, an inhibitor of early-stage autophagy, shows the inverse pattern (Figure 1)
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