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By keeping these molecules in check, glutathione helps protect your cellular integrity and supports your immune system

Key transcriptomic effects include upregulation of collagen synthesis genes (COL1A1, COL3A1), decorin, antioxidant genes (SOD1, CAT, GPX1), BDNF, neurotrophin receptors, and proteasome/ubiquitin pathway components

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Importantly, the expression of these genes is controlled by the transcription factor NRF2, and, in fact, the level of this protein was highly reduced in the most sensitive cell line, NCI H23, explaining the reduced expression of genes involved in GSH synthesis (Fig

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Wu J, Xu X, Zheng L, Mo J, Jin X, Bao Y