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Robert Kushner: I haven't seen that paper, but what I can say which I thought you were getting to is that when we look at the categorical weight loss in all these trials, so some people lose 5%, 10%, 20%, 25% over the course of the trial, if you then stop the medication, the individuals who lost the greatest amount of body weight actually are the ones that regain it the quickest
In contrast, the most recent studies have shown an increase in tumor development and metastasis in mouse models treated with vitamin E 155 (an opposite result of that in which high doses of vitamin C increase ROS levels to induce the death of colon cancer cells bearing KRAS and BRAF mutations) 156
This is unacceptable, Gillam said
What are the suggested dosages to get the best effect
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These compounds are chemically distinct from peptides in every way
