GLP-1 receptor agonists predominantly target non-MC4R-dependent neural pathways in mice 19 , and there is evidence from a small clinical study with liraglutide 20 that they may be effective in people with MC4R deficiency
25 , 16051612 (2004) Emsley, P
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However, combination therapy with sulfonylureas or insulin poses the risk of hypoglycemia
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