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Preliminary data published in June 2023 also suggests that GLP-1 drugs 'could modulate crucial pathways in the pathogenesis of inflammatory bowel disease (IBD), such as chronic inflammation circuits, intestinal tight junctions, and gut microbiome dysbiosis, setting the stage for human trials to investigate the role of these agents in the treatment of IBD among people with or without diabetes and obesity' (Arvanitakis, Theocharis, Popovic
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In SURMOUNT-1, tirzepatide 15 mg produced 20.9% weight loss over 72 weeks
Cleavage of SDF-1 by DPP-4 results in loss of activity (65), and consistent with this, DPP-4 inhibition in humans has been associated with enhancement of some effects which are associated with SDF-1 [increased levels of circulating endothelial progenitor cells (66) and increased distal tube sodium excretion (64)]
In a retrospective series of over 2,000 compounded lipotropic injections, the incidence of systemic hypersensitivity was below 0.1 percent, yet clinicians should maintain readiness to administer intramuscular epinephrine and transfer patients to higher-level care when indicated
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