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Congruently, the loss of KAT6A results in a shift in the expression of HOX genes (body segment identity), and the reduction in the expression of DLX genes (jaw and palate development) and TBX genes (heart development), among other affected genes (Voss et al, 2009, 2012
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In our study, we noted that liver fibrosis occurred in ob/ob mice fed the GAN diet, owing to the older age of ob/ob mice (25 weeks) and the long duration of their obesity
For instance, in IBS-C, a lower diurnal amplitude of phase III MMC activity fronts and impaired vagal cholinergic function are more pronounced, whereas in IBS-D repetitive and rapidly propagated bursts of contractions during phase II MMC, a shift toward sympathetic dominance and reduced vagal activity have been demonstrated [18-22]
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