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Cells 10 (11), 2849

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As a positive control, cells were treated with a supplier provided agent that induces cellular toxicity

Cross-threading or debris on threads can prevent proper sealing

In neurodegenerative disorders, including PD, it is hypothesized that persistent oxidative stress and proinflammatory activation of microglia contribute to the death of surrounding neurons (e.g., toxicity)

Genomic profiling published by Pickart and colleagues identified expression changes across roughly 4,000 human genes, spanning extracellular matrix biology, antioxidant defense, DNA repair, and tumor suppressor pathways